Dates back to at least the 15th century. Purchased by Charles Fitzroy (later Lord Southampton) and in 1761 he commissioned a survey of the land contained. It seems to have encompassed a large area of land with a very complex boundary. British History gives a detailed description but one would need a map, a pencil and probably an eraser to work it out. Let us know if you manage it.
The Manor House itself was located, as best we can tell, at the top of Tottenham Court Road, exactly where the Euston Road underpass now rumbles. Our picture, from Rocque's map of 1746, shows the house at the bottom right.