Event From 1665 To 1666
Europe suffered a number of bubonic plaque epidemics from 1347 – 1750. The last major outbreak in England was in 1665-6 and killed about 100,000 people, 20% of London’s population at the time. It was already mainly over by the time of the Great Fire. (A rather extreme example of the definition of history: One damn thing after another.) On the burial register at St Olaves, Hart Street are the names of 365 plaque victims.
Historic UK have produced a map of London plague pits.